Computational Modeling of Interacting VEGF and Soluble VEGF Receptor Concentration Gradients
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چکیده
منابع مشابه
Computational Modeling of Interacting VEGF and Soluble VEGF Receptor Concentration Gradients
Experimental data indicates that soluble vascular endothelial growth factor (VEGF) receptor 1 (sFlt-1) modulates the guidance cues provided to sprouting blood vessels by VEGF-A. To better delineate the role of sFlt-1 in VEGF signaling, we have developed an experimentally based computational model. This model describes dynamic spatial transport of VEGF, and its binding to receptors Flt-1 and Flk...
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Florence T. H. Wu, Marianne O. Stefanini, Feilim Mac Gabhann, Christopher D. Kontos, Brian H. Annex, and Aleksander S. Popel Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland; Department of Biomedical Engineering and Robert M. Berne Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia; Division of Cardiovascular M...
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BACKGROUND The aim of this study was to simultaneously measure the concentrations of vascular endothelial growth factor (VEGF) and soluble VEGF receptor-1 (sVEGFR-1, also known as sFlt-1) in the aqueous humor of patients with non-proliferative diabetic retinopathy (NPDR) and to investigate whether aqueous levels of vascular endothelial growth factor (VEGF) and VEGFR-1 are related to diabetic ma...
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ژورنال
عنوان ژورنال: Frontiers in Physiology
سال: 2011
ISSN: 1664-042X
DOI: 10.3389/fphys.2011.00062